Carel W le Roux Selected Research

Nausea

1/2023	Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial.
12/2021	Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial.
1/2021	Gastric emptying of solutions containing the natural sweetener erythritol and effects on gut hormone secretion in humans: A pilot dose-ranging study.
11/2019	Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial.
7/2015	A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management.
1/2008	Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake.
8/2006	The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients.

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Carel W le Roux Research Topics

Disease

114	Weight Loss (Weight Reduction) 03/2024 - 01/2006
109	Obesity 05/2024 - 01/2006
67	Type 2 Diabetes Mellitus (MODY) 02/2024 - 12/2010
36	Body Weight (Weight, Body) 02/2024 - 01/2006
18	Morbid Obesity 12/2022 - 09/2009
15	Diabetic Nephropathies (Diabetic Nephropathy) 12/2023 - 09/2014
14	Insulin Resistance 10/2022 - 12/2010
11	Neoplasms (Cancer) 11/2023 - 01/2011
11	Inflammation (Inflammations) 01/2022 - 05/2010
10	Albuminuria 11/2022 - 11/2014
9	Chronic Renal Insufficiency 02/2024 - 01/2018
7	Nausea 01/2023 - 08/2006
7	Overweight 12/2022 - 10/2012
6	Kidney Diseases (Kidney Disease) 12/2022 - 11/2013
6	Hypertension (High Blood Pressure) 12/2020 - 09/2009
5	Diabetes Mellitus 05/2022 - 02/2013
4	Prediabetic State (Prediabetes) 12/2022 - 01/2017
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 01/2011
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2024 - 01/2021
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2024 - 01/2016
3	Non-alcoholic Fatty Liver Disease 01/2023 - 10/2018
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2021 - 01/2020
3	Diabetes Complications 01/2021 - 09/2014
3	Hypertrophy 07/2010 - 09/2007
2	Hyperphagia (Overeating) 10/2023 - 10/2012
2	Hypoglycemia (Reactive Hypoglycemia) 01/2023 - 09/2012
2	Fibrosis (Cirrhosis) 01/2023 - 01/2021
2	Alcoholic Fatty Liver 01/2023 - 01/2022
2	Vomiting 01/2023 - 01/2021
2	Endometrial Neoplasms (Endometrial Cancer) 11/2022 - 01/2022
2	Chronic Disease (Chronic Diseases) 01/2022 - 01/2018
2	Esophageal Neoplasms (Esophageal Cancer) 01/2021 - 01/2019
2	Proteinuria 12/2020 - 07/2013
2	Necrosis 01/2020 - 01/2018
2	Infections 11/2019 - 03/2014
2	Cachexia 06/2019 - 12/2016
2	Dumping Syndrome (Syndrome, Dumping) 07/2017 - 06/2014
2	Glucose Intolerance 01/2017 - 09/2012
2	Diarrhea 07/2015 - 11/2009
2	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2015 - 02/2013
2	Metabolic Diseases (Metabolic Disease) 03/2013 - 02/2013

Drug/Important Bio-Agent (IBA)

31	Glucose (Dextrose)FDA LinkGeneric 02/2024 - 07/2012
30	Hormones (Hormone)IBA 11/2022 - 01/2006
22	Glucagon-Like Peptide 1 (GLP 1)IBA 03/2024 - 09/2007
18	Insulin (Novolin)FDA Link 12/2023 - 12/2010
13	Liraglutide FDA Link 05/2024 - 02/2015
13	Peptides (Polypeptides)IBA 02/2024 - 05/2008
12	semaglutideIBA 05/2024 - 11/2019
11	salicylhydroxamic acid (SHAM)IBA 12/2020 - 05/2010
10	Bile Acids and Salts (Bile Acids)IBA 01/2021 - 11/2009
9	Glucagon-Like Peptide-1 ReceptorIBA 02/2024 - 01/2018
9	Biomarkers (Surrogate Marker)IBA 01/2023 - 09/2011
8	Peptide YYIBA 03/2016 - 08/2006
7	tirzepatideIBA 05/2024 - 11/2022
6	Glucagon (Glukagon)FDA Link 02/2024 - 09/2012
6	LipidsIBA 11/2022 - 02/2013
6	GhrelinIBA 01/2021 - 08/2006
5	LeptinIBA 01/2022 - 03/2011
5	Blood Glucose (Blood Sugar)IBA 01/2021 - 02/2015
5	CreatinineIBA 01/2020 - 06/2017
4	Glucagon-Like Peptide-1 Receptor AgonistsIBA 03/2024 - 01/2022
4	Sodium-Glucose Transport ProteinsIBA 02/2024 - 09/2023
4	CholesterolIBA 02/2024 - 09/2017
4	Fatty Acids (Saturated Fatty Acids)IBA 11/2022 - 05/2014
4	Triglycerides (Triacylglycerol)IBA 02/2022 - 04/2015
4	AlbuminsIBA 01/2020 - 06/2017
3	IncretinsIBA 01/2023 - 03/2014
3	HDL CholesterolIBA 01/2023 - 01/2021
3	C-Reactive ProteinIBA 01/2022 - 01/2018
3	GlicentinIBA 01/2021 - 01/2020
3	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 02/2015
3	Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA 01/2020 - 05/2008
3	CytokinesIBA 01/2016 - 05/2012
2	Naltrexone (ReVia)FDA LinkGeneric 05/2024 - 07/2022
2	Bupropion (Wellbutrin)FDA LinkGeneric 05/2024 - 07/2022
2	SodiumIBA 02/2024 - 01/2023
2	Sodium-Glucose Transporter 2 InhibitorsIBA 11/2023 - 11/2019
2	MelanocortinsIBA 10/2023 - 07/2012
2	MicronutrientsIBA 02/2021 - 01/2019
2	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA 01/2021 - 08/2009
2	Phenobarbital (Luminal)FDA Link 12/2020 - 01/2011
2	CanagliflozinIBA 01/2020 - 11/2019
2	Proteins (Proteins, Gene)FDA Link 12/2018 - 01/2017
2	Peptide Hormones (Polypeptide Hormones)IBA 01/2018 - 01/2015
2	CarbohydratesIBA 07/2017 - 07/2012
2	Calcium Gluconate (CBG)IBA 03/2010 - 11/2009
2	Hydrocortisone (Cortisol)FDA LinkGeneric 03/2010 - 11/2009

Therapy/Procedure

115	Bariatric Surgery 12/2023 - 01/2006
66	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2023 - 11/2007
32	Therapeutics 11/2023 - 01/2009
16	Gastrectomy 02/2024 - 07/2013
15	Glycemic Control 02/2024 - 01/2006
10	Drug Therapy (Chemotherapy) 11/2023 - 05/2014
5	Biliopancreatic Diversion 01/2018 - 09/2007
4	Obesity Management 12/2022 - 01/2022
3	Injections 09/2023 - 03/2022
3	Esophagectomy 01/2021 - 01/2019
2	Length of Stay 01/2021 - 03/2014
2	Combined Modality Therapy 01/2019 - 09/2015
2	Operative Surgical Procedures 08/2017 - 07/2013